Takao Matsubara Selected Research

Acridine Orange

9/2018	Long-term clinical outcome in patients with high-grade soft tissue sarcoma who were treated with surgical adjuvant therapy using acridine orange after intra-lesional or marginal resection.
7/2014	Determination of the LD50 of acridine orange via intravenous administration in mice in preparation for clinical application to cancer therapy.
3/2013	Can a less radical surgery using photodynamic therapy with acridine orange be equal to a wide-margin resection?
1/2012	Translational research of photodynamic therapy with acridine orange which targets cancer acidity.
12/2011	Acridine orange inhibits pulmonary metastasis of mouse osteosarcoma.
9/2010	Clinical outcomes of minimally invasive surgery using acridine orange for musculoskeletal sarcomas around the forearm, compared with conventional limb salvage surgery after wide resection.
1/2010	In vivo anti-tumor activity of photodynamic therapy with intravenous administration of acridine orange, followed by illumination with high-power flash wave light in a mouse osteosarcoma model.
1/2009	A new therapeutic modality involving acridine orange excitation by photon energy used during reduction surgery for rhabdomyosarcomas.
5/2008	Methylene blue in place of acridine orange as a photosensitizer in photodynamic therapy of osteosarcoma.
5/2008	A new limb salvage surgery in cases of high-grade soft tissue sarcoma using photodynamic surgery, followed by photo- and radiodynamic therapy with acridine orange.

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Takao Matsubara Research Topics

Disease

34	Neoplasms (Cancer) 10/2020 - 02/2005
29	Sarcoma (Soft Tissue Sarcoma) 04/2019 - 03/2005
12	Osteosarcoma (Osteogenic Sarcoma) 01/2018 - 05/2005
10	Neoplasm Metastasis (Metastasis) 01/2017 - 02/2005
3	Synovial Sarcoma (Synovioma) 04/2019 - 05/2005
3	Hypoxia (Hypoxemia) 01/2018 - 12/2006
3	Hyperthermia 10/2014 - 01/2007
3	Neurofibrosarcoma (MPNST) 10/2007 - 02/2005
2	Angina Pectoris 01/2019 - 10/2014
2	Infections 01/2019 - 01/2016
2	Wound Infection (Wound Infections) 01/2016 - 06/2015
2	Margins of Excision 03/2013 - 09/2007
1	Hypertension (High Blood Pressure) 10/2020
1	Esophageal Squamous Cell Carcinoma 04/2019
1	Melanoma (Melanoma, Malignant) 04/2019
1	Testicular Neoplasms (Testicular Cancer) 04/2019
1	Ischemia 01/2019
1	Myocardial Ischemia (Ischemic Heart Diseases) 01/2019
1	Death (Near-Death Experience) 12/2016
1	Myocardial Infarction 12/2016
1	Heart Failure 12/2016
1	Cardiovascular Diseases (Cardiovascular Disease) 12/2016
1	Fever (Fevers) 11/2016
1	Wounds and Injuries (Trauma) 01/2016
1	Thrombosis (Thrombus) 10/2014
1	False Aneurysm (Pseudoaneurysm) 11/2012
1	Acute Coronary Syndrome 09/2012
1	Contracture 04/2011
1	Ventricular Fibrillation 09/2010
1	Brugada Syndrome 09/2010
1	Sudden Death 09/2010
1	Necrosis 01/2010
1	Pneumothorax 08/2009
1	Torsades de Pointes (Torsade de Pointes) 03/2009
1	Rhabdomyosarcoma 01/2009

Drug/Important Bio-Agent (IBA)

16	Acridine OrangeIBA 09/2018 - 02/2005
10	1-phenyl-3,3-dimethyltriazene (PDT)IBA 01/2012 - 03/2005
6	C-Reactive ProteinIBA 01/2017 - 02/2012
3	Oxygen (Dioxygen)IBA 01/2013 - 03/2007
3	Proteins (Proteins, Gene)FDA Link 09/2012 - 12/2006
2	Pharmaceutical PreparationsIBA 01/2019 - 12/2016
2	cytidylyl-(3'-5')-cytidine (CpC)IBA 01/2016 - 03/2006
2	calcium phosphateIBA 01/2016 - 03/2006
2	EnzymesIBA 01/2012 - 03/2007
2	Protons (Proton)IBA 01/2012 - 03/2007
2	brilliant green (ethyl green)IBA 12/2011 - 01/2006
2	XenonIBA 01/2010 - 09/2007
2	DecorinIBA 06/2008 - 10/2007
2	Extracellular Matrix ProteinsIBA 06/2008 - 10/2007
2	Biomarkers (Surrogate Marker)IBA 10/2007 - 12/2006
1	LipidsIBA 10/2020
1	LDL CholesterolIBA 10/2020
1	AntigensIBA 04/2019
1	Carbonic Anhydrase IXIBA 01/2018
1	Interleukin-6 (Interleukin 6)IBA 01/2017
1	Hemoglobins (Hemoglobin)IBA 01/2017
1	omega-Chloroacetophenone (Mace)IBA 12/2016
1	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 12/2016
1	Naproxen (Naprosyn)FDA LinkGeneric 11/2016
1	Fibrinogen (Factor I)FDA Link 01/2016
1	Glycoproteins (Glycoprotein)IBA 01/2016
1	Indicators and Reagents (Reagents)IBA 09/2015
1	Anti-Bacterial Agents (Antibiotics)IBA 06/2015
1	MetalsIBA 10/2014
1	FibrinIBA 10/2014
1	Biocompatible Materials (Biomaterials)IBA 10/2014
1	Paclitaxel (Taxol)FDA LinkGeneric 10/2014
1	Sirolimus (Rapamycin)FDA Link 10/2014
1	matrigelIBA 01/2013
1	Messenger RNA (mRNA)IBA 09/2012
1	Fatty Acids (Saturated Fatty Acids)IBA 01/2012
1	Proton Pumps (Proton Pump)IBA 01/2012
1	pilsicainideIBA 09/2010
1	Lidocaine (Xylocaine)FDA LinkGeneric 03/2009
1	Biological ProductsIBA 06/2008
1	Methylene Blue (Methylthioninium Chloride)FDA Link 05/2008

Therapy/Procedure

13	Therapeutics 09/2018 - 02/2005
11	Photochemotherapy (Photodynamic Therapy) 12/2017 - 02/2005
5	Drug Therapy (Chemotherapy) 10/2014 - 02/2005
4	Minimally Invasive Surgical Procedures 08/2016 - 03/2008
4	Limb Salvage 03/2013 - 03/2005
3	Radiofrequency Ablation 01/2017 - 08/2009
3	Radiotherapy 08/2016 - 01/2007
3	Curettage 01/2016 - 03/2005
3	Intravenous Administration 07/2014 - 01/2006
2	Debridement 01/2019 - 01/2016
2	Metastasectomy 01/2017 - 03/2011
2	Percutaneous Coronary Intervention 12/2016 - 09/2012
1	Immunotherapy 04/2019
1	Reoperation 01/2019
1	Prostheses and Implants (Prosthesis) 01/2019
1	Extracorporeal Shockwave Therapy 01/2019
1	Operative Surgical Procedures 01/2016
1	Microspheres (Microsphere) 10/2014
1	Stents 10/2014
1	Conservative Treatment 11/2012
1	Oncolytic Virotherapy 09/2012
1	Treatment Delay 12/2011
1	Withholding Treatment 03/2011
1	Chest Tubes (Chest Tube) 08/2009